Vareed SK, Reddy MK, Schutzki RE, Nair MG. Physico-chemical and antioxidant properties of cornelian cherry fruits ( Cornus mas L.) grown in Turkey. Physicochemical and organoleptic properties of yogurt with cornelian cherry paste. leaves on the kidney function tests and histological structures in streptozotocin-induced diabetic rats. Hassanalilou T, Payahoo L, Shahabi P, Abbasi MM, Jafar-abadi MA, Bishak YK, et al. Residue from star fruit as valuable source for functional food ingredients and antioxidant nutraceuticals. Hepatoprotective effect of Ficus religiosa latex on cisplatin induced liver injury in Wistar rats. World Acad Sci Eng Technol Int J Med Health Biomed Bioeng Pharm Eng. Hepatoprotective effect of oleuropein against cisplatin-induced liver damage in rat. 2017 49:49.Ĭerig S, Geyikoglu F, Bakir M, Colak S, Sonmez M, Koc K. Effect of daidzein on cisplatin-induced hematotoxicity and hepatotoxicity in experimental rats. The results showed antioxidant and phenol contents in Cornus mas fruit could improve Cis-induced oxidative stress and liver histologic changes in rats. Evaluating the histological structure of liver tissue, it was found that treatment by CMFE could ameliorate the Cis-induced changes to near normal histology. Oral administration of CMFE for 16 days in the two different dosages at 300 and 700 mg/kg improved the Cis-induced changes of liver enzymes activity and serum enzymes level. Moreover, exposure to Cis caused a reduction in serum level of AST, ALT, and ALP and a rise in serum level of GGT. Cis caused reduction in the activity of liver antioxidant enzymes including SOD, GPx, TAC, and CAT and increased that of MDA. After the intervention, blood and tissue samples were taken for biochemical and histopathological analysis. Forty Wistar rats were divided into a control group, cisplatin (Cis) group, CMFE group, CMFE 300 + Cis group, and the CMFE 700 + Cis group. The present study was aimed to investigate whether Cornus mas fruit hydro-methanolic extract (CMFE) can modulate the cisplatin-induced changes in liver antioxidant enzymes and histological structure. Cornelian cherry ( Cornus mas) is a valuable source of phenolic antioxidants.
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